>AIE Fluorescent dye TingoRed

AIE fluorescent Dye is a product based on current research hotspots in the field of organic luminescent materials. Aggregation-induced emission (AIE) ". Theoretical new fluorescent imaging materials. In other words, the restriction of intramolecular rotation of fluorescent molecules in the aggregation state leads to the obstruction of non-radiative decay channels and thus the enhancement of fluorescent radiation. AIE fluorescent dyes overcome the occurrence of traditional fluorescent materials in the aggregation state. "Aggregation caused quenching, ACQ." It has the advantages of good and adjustable fluorescent luminous efficiency, good light stability, high sensitivity, low signal-to-noise ratio, high selectivity and good biocompatibility. In the past 20 years since the development of AIE theory, AIE fluorescent dyes have been successfully applied in life science and biomedical fields such as cell imaging, biological detection, anti-cancer and gene drug delivery, diagnosis and treatment of major diseases, and are expected to become a new generation of intelligent biomedical materials.

Tianjiu Regenerative Medicine is committed to the in vivo tracer imaging of stem cells and exosomes after delivery of AIE technology in the field of regenerative medicine, to build the largest AIE biomedical technology transformation base in China. At present, Tianjiu Regenerative Medicine, in cooperation with the team of Academician Benzhong Tang, founder of AIE technology, and Professor Ding Dan of Nankai University, has successfully developed a red AIE fluorescent dye product: TingoRed, which is used for cell and exosome labeling.

>High purity hepatocyte differentiation system derived from human pluripotent stem cells
TingoHep Human PSC to Hepatocyte Differentiation System

Hepatocyte model has broad application prospects in the study of liver development mechanism, pathological analysis, drug screening, and target discovery. However, taking individual primary hepatocytes as the source of materials has a series of insurmountable problems, such as high difficulty in obtaining, large batch difference, and unstable supply. Therefore, the method of mass-transforming pluripotent stem cells (PSCS) to produce liver cells has significant advantages. TingoHep Human PSC to Hepatocyte Differentiation System can achieve stable and large-scale induced transformation into hepatocyte production.

Product Advantage:
(1) High induction efficiency (ALB+ cells > 90%).
(2) hepatocellular specific functions, including drug metabolism (CYP3A4 expression).
(3) Excellent system stability.

>Novel coronavirus antigen test kit

Viral nucleocapsid protein (N protein) is the most abundant protein in coronaviruses, which is highly conserved. Nucleocapsid phosphoprotein packages the viral genome into helical nucleocapsid, so it plays an important role in the self-assembly of the virus. At the same time, N protein is also involved in viral genome replication and regulation of cell signaling pathways. Therefore, N protein is used as a diagnostic test tool for coronavirus and is the basis of rapid diagnostic reagents for immunology.

Relying on AIE technology platform, Tianjiu Regenerative Medicine has established immunological detection methods for novel coronavirus antigen, and developed in vitro diagnostic reagent products with high sensitivity, stable performance, accuracy and speed. The novel coronavirus (2019-nCoV) antigen assay kit (AIE fluorescence immunochromatography) was used to qualitatively detect viral nucleocapsid protein (N protein) in throat swab samples. No specific instruments were required and the results could be interpreted by illuminating the detection window with a portable ultraviolet lamp. Antigen detection can be used as a supplement to existing detection methods to quickly detect positive cases during the infection period, and can be used for early identification, rapid screening and management of suspected populations.

>Polypeptide gel series products

Tianjiu Regenerative Medicine's peptide hydrogels team has 20 years of research experience in the field of self-assembled peptide gels. Its peptide gels series include gel adjuvant SupraAdjuvant, IGF-1 growth factor simulation peptide SupraIGF-I and PDGF growth factor simulation peptide SupraPDGF.

SupraAdjuvant gel adjuvants can significantly enhance the titer of the target antibodies, especially for the preparation of antibodies to modified proteins such as phosphorylation and acetylation. At the same time, the product can effectively activate cellular immunity, and can be used in the research and development of vaccines for cancer, AIDS and other major diseases.

SupraIGF-I insulin growth factor simulated peptide has the effect of promoting cell growth and anti-apoptosis, and is suitable for efficient expansion of stem cells and primary cells such as HUVEC, MSC, and islet primary cells in vitro and transplantation in vivo.

SupraPDGF can effectively promote the growth of fiber cells, epidermal cells and other cells, and has the effect of promoting wound repair, anti-wrinkle and anti-aging.

>Transfection reagent Polyfectamine^® Reagent

Polyfectamine is an organic nanomolecular molecule with high cationic charge density. Every two carbon atoms separated by polyfectamine are protonated amino nitrogen atoms, which makes the polymer network can act as an effective proton sponge body at any pH, and therefore has higher transfection efficiency.

Polyfectamine condenses DNA into positively charged particles that can stick to negatively charged cell surface residues and enter the cell through endocytosis. Once inside the cell, protonation of the amine results in an influx of counter ions and a decrease in osmotic potential. The osmotic expansion caused by these changes causes the vesicles to release polymer-DNA complex (Polyplex) into the cytoplasm. When the complex is dismantled, the DNA is free to fuse into the nucleus. As a synthetic organic nanomolecular material, Ployfectamine has no easy decomposition or enzymolysis groups, so it has good stability and will not be affected by temperature, pH, light and other external factors.