Study on the preparation of bovine milk exosomes and the stability of lyophilized powder
Release time：
2024-07-12
Source：
https://doi.org/10.1101/2023.10.16.562624
Author：Lu Lu1,#, Chunle Han1,#, Miao Wang1,#, Huanqing Du1,#, Ning Chen1,#, Mengya Gao1,#, Na Wang1 , Dongli Qi1 , Wei Bai1 , Jianxin Yin1 , Fengwei Dong1 , Tianshi Li2,*, Xiao Hu Ge1,*
Release date：2023-10-19
ABSTRACT：Bovune milk exosomes (MK-exo) have bioactive effects on the health of consumers and can also serve as excellent drug delivery vehicles. However, long-term preservation and transportation remain major challenges at present. In this report, high-quality MK-exo are prepared on a large scale. We then developed a lyophilization method belonging to MK-exo, and performed acceleration and long-term stability experiments on the lyophilized MK-exo to evaluate the effect of lyophilization. The results showed that the lyophilized MK-exo can be stored at room temperature for at least 3 months and 2-8°C℃ for 15 months. These findings provide data support for further understanding of the properties and applications of MK-exo.
Article download：Study on the preparation of bovine milk exosomes and the stability of lyophilized .pdf
